Luis Suarez and Ousmane Dembele are out with injuries and will certainly miss the clash.
Neto is still in doubt for the match after picking up an injury against Ibiza.
Leganes are set to miss Alexander Szymanowski and Dimitris Siovas.
Barcelona have won four and lost one of the last five games against Leganes.
With Quique Setien in charge, Barca have won two out of three games.
The Catalans have scored three goals and conceded three goals since the new manager arrived.
Barca probable XI: Neto; Roberto, Pique, Lenglet; Busquets; Semedo, De Jong, Vidal, Firpo; Messi, Griezmann.
Leganes's probable XI
Soriano; Rosales, Tarin, Bustinza, Silva; Perez, Eraso; Ruibal, Mourid, Braithwaite; Carrillo
⚽ Score predictions
90min's Alfie Steiner: Barcelona 3-1 Leganes
"After last year's shock 2-1 defeat to Valencia in the Copa del Rey final, Barcelona will be desperate to regain their Copa crown. No team has won the competition more than the Catalans.
"It will be somewhat of a miracle if, at the Nou Camp, Leganes are able to come away with a positive result. However, Barcelona find themselves in somewhat of a slump, so Leganes will feel this is as good a time as any to take on the Spanish giants.
"However, the home side should have more than enough to secure victory on Thursday.
"Barcelona have won 6 of their last 7 matches against Leganes. When those two sides met in La Liga at the Estadio Municipal de Butarque in November, the Catalans secured a 2-1 win. Barcelona will want to make an immediate statement after last Saturday’s defeat against Valencia and we are backing them to win to nil this match.
"Leganes have been rather poor on the road and have problems to score goals so we don't see them register at Camp Nou. We are going for 3-0 Barcelona in the correct score market."
De Jong vs Eraso
Javier Eraso is a man with a lot of experience in Spanish football, having played for Athletic Bilbao and Leganes. Meanwhile, Frenkie de Jong has been struggling recently. The Dutchman needs to start creating scoring opportunities for his teammates and not just pass the ball sideways. So, if Frenkie manages to beat Eraso in the midfield area, he could put in a decent performance to reassure the fans and the club of his true talents.
⚽ Managers' quotes
Quique Setien: "It is a very important match. We all want to win in the knockout tie and stay in the Cup until the end. Our goal is always to control the match, lead the way and try to minimize the opponent's options.
"We must not underestimate Leganes. They are a team who have nothing to lose, and playing against them will not be easy."
Javier Aguirre: "We want to move on to the next round, we have high ambitions because it's a single knockout match. I would not say that we are favourites because it would be a law, but we will have our chance in Barcelona."
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